Search results for "tumor therapy"
showing 10 items of 21 documents
Progress of Phototherapy Applications in the Treatment of Bone Cancer
2021
Bone cancer including primary bone cancer and metastatic bone cancer, remains a challenge claiming millions of lives and affecting the life quality of survivors. Conventional treatments of bone cancer include wide surgical resection, radiotherapy, and chemotherapy. However, some bone cancer cells may remain or recur in the local area after resection, some are highly resistant to chemotherapy, and some are insensitive to radiotherapy. Phototherapy (PT) including photodynamic therapy (PDT) and photothermal therapy (PTT), is a clinically approved, minimally invasive, and highly selective treatment, and has been widely reported for cancer therapy. Under the irradiation of light of a specific wa…
Not just for tumor targeting: unmet medical needs and opportunities for nanomedicine.
2015
During the last 3 decades, nanomedicines have provided novel opportunities to improve the delivery of chemotherapeutics in cancer therapy effectively. However, many principles learnt from there have the potential to be transferred to other diseases. This perspective article, on the one hand, critically reflects the limitations of nanomedicines in tumor therapy and, on the other hand, provides alternative examples of nanomedicinal applications in immunotherapy, noninvasive drug deliveries across epithelial barriers and strategies to combat intra- and extra-cellular bacterial infections. Looking ahead, access to highly complex nanoparticular delivery vehicles given nowadays may allow further…
Individualized Tumor Therapy: Biomarkers and Possibilities for Targeted Therapy with Natural Products
2014
Although many tumors respond to chemotherapy, not all patients benefit from anticancer drugs. Tumors often develop resistance to drugs and concentrations sufficient to eradicate the cancer cannot be used due to the severe side effects of chemotherapy. In the present chapter, we give an overview of research on biomarkers with prognostic and predictive value and summarize our own efforts in this context. With a battery of biomarkers and corresponding synthetic and natural targeted drugs, it is likely that custom-tailored combination treatments will soon become a reality and that each individual cancer patient will be treated based on his or her individual molecular tumor architecture.
Development of primary human NSCLC patient derived xenograft and organoids models as a precision approach to tumor treatment
2018
Injectable Hydrogel for Synergetic Low Dose Radiotherapy, Chemodynamic Therapy and Photothermal Therapy
2021
Higher doses of radiotherapy (RT) are associated with resistance induction, therefore highly selective and controllable radiosensitizers are urgently needed. To address this issue, we developed a FeGA-based injectable hydrogel system (FH) that can be used in combination with low-dose radiation. Our FH can deliver FeGA directly to the tumor site via intratumoral injection, where it is a reservoir-based system to conserve FeGA. The photothermal properties of FeGA steadily dissolve FH under laser irradiation, and, simultaneously, FeGA reacts with a large amount of H2O2 in the cell to produce OH (Fenton reaction) which is highly toxic to mitochondria, rendering the cell inactive and reducing ra…
IAP proteins as targets for drug development in oncology.
2013
The inhibitors of apoptosis (IAPs) constitute a family of proteins involved in the regulation of various cellular processes, including cell death, immune and inflammatory responses, cell proliferation, cell differentiation, and cell motility. There is accumulating evidence supporting IAP-targeting in tumors: IAPs regulate various cellular processes that contribute to tumor development, such as cell death, cell proliferation, and cell migration; their expression is increased in a number of human tumor samples, and IAP overexpression has been correlated with tumor growth, and poor prognosis or low response to treatment; and IAP expression can be rapidly induced in response to chemotherapy or …
ENGINEERED NANOGELS FOR BIOLOGICAL DRUGS TRANSPORT
2009
Nowadays the nanocarrier strategy, aimed to rebuild the tumor therapy approach in a winning way, is growing very fast. This is in the direction to engender nanocarriers having synergistic action by the “biological drugs” transported, the capability to recognize specific targets and the molecular architecture that allows them to perform at the best their therapeutic functions. We are building engineered nanocarriers having different functions (control cell cycle, induce apoptosis, etc.) as well as the capability to recognize specific targets (tumor cells, angiogenic and/or sprouting endothelial cells); moreover, they must have also the ability to escape the host immunosystem, such that not t…
Engineered Multifunctional Nanotools for Biological Applications
2011
Smart multifunctional magnetic nanoparticles are popular candidates for several biological applications owing to their intrinsic magnetic property and diverse applications that range from rare protein separation and biomedical utilization to cancer therapy and diagnostics. A universal protocol, for the development of such nanocarriers, is highly desirable for scientists with different backgrounds so that custom-made multifunctional nanoparticles can be developed to address their needs, among which are the superparamagnetic iron oxide and manganese oxide nanoparticles that are synthesized through high temperature decomposition reactions. However, an interface is needed to present these inorg…
Microcells Development and Endocytosis Ability Morphological and Quantitative Characterization in HeLa Cancer Cells
2008
Determination of endocytotic ability of cancer cells could improve tumor treatment results. The aim of this study was to investigate morphological aspects of development in HeLa (Henrietta Lacks cervical cancer cells) microcells and to quantitatively estimate the endocytotic capability of these cells.